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dr 314 graham kerr building institute of biodiversity, animal health and comparative medicine university of glasgow glasgow g12 8qq e: [email protected] t: 0141 330 6638 w: www.richardorton.co.uk about me i am a postdoctoral research associate at the institute of biodiversity, animal health and comparative medicine, university of glasgow. i am currently employed on a bbsrc project entitled “beyond the consensus - dissecting viral sequence diversity within samples” where i am using next generation sequencing to analyse the sequence diversity of the foot-and-mouth disease virus within and between hosts. my research all centres around the field of computational biology and can be split into three different areas - bioinformatics, systems biology, and epidemiology. bioinformatics i am interested in the visualisation and integration of biological data from different omic strategies (sequence, expression, interaction, pathways, models etc) and the development of software tools to aid in their analysis. i am currently working on the integration of computational models with the underlying biological data, and the application of next generation sequencing technologies to the study of viral populations to further our understanding of genetic diversity and bottlenecks at various scales. systems biology i am interested in the computational modelling of biological pathways with my main research relating to the mapk/erk pathway, its role in cell signalling from different growth factor receptors, and how it is deregulated to cause cancer. i am particularly interested in the role negative feedback loops play in signalling and the drug resistance properties they can give a cancerous system. i am also interested in the development of computational tools for the simulation of pathways, and the development and management of models. epidemiology i am interested in the computation modelling of infectious diseases with my main research focusing on the modelling of various livestock disease in gb such as bovine tuberculosis (btb), bluetongue virus and foot-and-mouth disease (fmd) using both stochastic and probabilistic approaches to model the spatial spread of diseases via movements and local spread via vectors and wildlife reservoirs. background 2012 - present: research associate (dan haydon), university of glasgow bioinformatics - next generation sequence analysis of fmd disease within and between hosts - diversity and genetic bottlenecks at different scales - software development of viral ngs analysis pipeline. 2009 - 2012: scientific programmer (rowland kao), university of glasgow epidemiology - stochastic and probabilistic modelling of the dynamics and spatial spread of fmd, btb and bluetongue diseases in british livestock - software development of modelling framework - c++, mysql and gis. 2008 - 2009: software developer, jpmorgan software developer working on kapital (interest rate derivates) for the securitized products group, new york - smalltalk and gemstone. 2003 - 2008: research associate (david gilbert), university of glasgow systems biology - computational modelling of cell signalling and cancer pathways, negative feedback loops and drug resistance - software development of model simulation and management tools - java, php, mysql and odes. 2000 - 2003: phd student (dietlind gerloff), university of edinburgh bioinformatics - visualisation, integration and analysis of genomic and functional genomic data sets for yeast - java, perl and mysql. 1999 - 2000: genotyper, oxagen ltd bioinformatics - qc and analysis of genotype data (variable repeat markers) to associate chromosomal regions from within diseased families to diseases such as diabetes. 1996 -1999: undergraduate student, university of birmingham bsc (hons) biochemistry with biotechnology. publications observing micro-evolutionary processes of viral populations at multiple scales orton rj, wright cf, morelli mj, juleff n, thebaud g, knowles nj, valdazo-gonzalez b, paton dj, king dp, haydon dt phil trans of the royal society of london series b: biological sciences (2013) 368 developing a framework for risk-based surveillance of tuberculosis in cattle: a case study of its application in scotland bessell p, orton r, o'hare a, mellor d, logue d, kao r epidemiology and infection (2012) 141 (2). pp. 314-323 whole genome sequencing reveals local transmission patterns of mycobacterium bovis in sympatric cattle and badger populations biek r, o'hare a, wright d, mallon t, mccormick c, orton rj, mcdowell s, trewby h, skuce ra, kao rr plos pathogens (2012) 8 (11) risk of foot-and-mouth disease spread due to sole occupancy authorities and cts linked holdings orton rj, bessell br, birch c, o’hare a, kao rr plos one (2012) 7 (4) risk factors for bovine tuberculosis at the national level in great britain bessell br, orton rj, kao rr bmc veterinary research (2012) vol 8 article 51 the mammalian mapk/erk pathway exhibits properties of a negative feedback amplifier sturm oe, orton rj, grindlay j, birtwistle m, vyshemirsky v, gilbert d, calder m, pitt a, kholodenko b, kolch w science signalling 3 (2010), ra90 computational modelling of kinase signalling cascades gilbert dr, heiner m, breitling r, orton r methods in molecular biology (2010) 661:369-84 cell fate decisions specified by the dynamic erk interactome von kriegsheim a, baiocchi d, birtwistle m, sumpton d, bienvenut w, morrice n, yamada k, lamond a, kalna g, orton r, gilbert d, kolch w nature cell biology (2009), 11: 1458-1464 computational modelling of cancerous mutations in the egfr/erk signalling pathway orton rj, adriaens me, gormand a, sturm oe, kolch w, gilbert dr bmc systems biology (2009), vol 3 article 100 version control of pathway models using xml patches saffrey p, orton r bmc systems biology (2009), vol 3, article 34 computational modelling reveals feedback redundancy within the egfr/erk signalling pathway orton rj, sturm o, gormand a, kolch w and gilbert d iet systems biology, vol 2 issue 4, 173-183, july 2008 a structured approach for the engineering of biochemical network models, illustrated for signalling pathways breitling r, gilbert d, heiner m, orton r (2008). briefings in bioinformatics, june 23, 2008. computational methodologies for modelling, analysis and simulation of signalling networks gilbert d, fuss h, gu x, orton rj, robinson s, vyshemirsky v, kurth mj, downes cs, and dubitzky w briefings in bioinformatics 2006 7: 339-353 analysis of signalling pathways using continuous time markov chains calder m, vyshemirsky v, gilbert d, and orton rj transactions on computational systems biology vi, vol. 4220, pp. 44-67, springer, 2006 computational modelling of the receptor tyrosine kinase activated mapk pathway orton rj, sturm oe, vyshemirsky v, calder m, gilbert dr, kolch w biochemical journal: vol 392 (2) 249-261, 01/12/2005 analysis of signalling pathways using the prism model checker calder m, vyshemirsky v, gilbert d, orton rj proceedings of computational methods in systems biology (cmsb) 2005 yeti: yeast exploration tool integrator orton rj, sellers wi, gerloff dl bioinformatics: january 22nd 2004: 20(2): 284-5 computer-aided visualisation of archaeological caves sellers wi, orton r, chamberlain at capra: november 2001 (3) also acknowledged in - a unifying framework for modelling and analysing biochemical pathways using petri nets gilbert d, heiner m, lehrack s proceedings of computational methods in systems biology (cmsb) 2007 modelling the influence of rkip on the erk signalling pathway using the stochastic process algebra pepa calder m, gilmore s and hillston j transactions on computational systems biology vii, vol. 4230, pp. 1-23, springer, 2006 stronger computational modelling of signalling pathways using both continuous and discrete-space methods calder m, duguid a, gilmore s, and hillston j proceedings of computational methods in systems biology (cmsb) 2006 reasoning about the erk signal transduction pathway using biosignet-rr sh

URL analysis for richardorton.co.uk

http://www.richardorton.co.uk/./mapk/
http://www.richardorton.co.uk/./egf/
yeti.mapk.org.uk
compbio.dcs.gla.ac.uk
brc.dcs.gla.ac.uk

Whois Information

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Domain name:
richardorton.co.uk

Data validation:
Nominet was able to match the registrant's name and address against a 3rd party data source on 10-Dec-2012

Registrar:
1 & 1 Internet SE [Tag = 1AND1]
URL: https://www.1and1.co.uk

Relevant dates:
Registered on: 07-Nov-2006
Expiry date: 07-Nov-2018
Last updated: 08-Mar-2018

Registration status:
Registered until expiry date.

Name servers:
ns1064.ui-dns.biz
ns1064.ui-dns.com
ns1064.ui-dns.de
ns1064.ui-dns.org

WHOIS lookup made at 13:19:55 26-Jun-2018

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  REFERRER http://www.nominet.org.uk

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SERVERS

  SERVER co.uk.whois-servers.net

  ARGS richardorton.co.uk

  PORT 43

  TYPE domain

DOMAIN

SPONSOR
1 & 1 Internet SE [Tag = 1AND1]
URL: https://www.1and1.co.uk
Relevant dates:

  CREATED 07-Nov-2006

  CHANGED 08-Mar-2018

STATUS
Registered until expiry date.

NSERVER

  NS1064.UI-DNS.BIZ 217.160.81.64

  NS1064.UI-DNS.COM 217.160.82.64

  NS1064.UI-DNS.DE 217.160.80.64

  NS1064.UI-DNS.ORG 217.160.83.64

  NAME richardorton.co.uk

DISCLAIMER
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for .uk domain names. This information and the .uk WHOIS are:
Copyright Nominet UK 1996 - 2018.
You may not access the .uk WHOIS or use any data from it except as permitted
by the terms of use available in full at https://www.nominet.uk/whoisterms,
which includes restrictions on: (A) use of the data for advertising, or its
repackaging, recompilation, redistribution or reuse (B) obscuring, removing
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  REGISTERED no

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